• A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae

    Tsuyoshi Uehara, Allison L Zulli, Brittany Miller, Lindsay M Avery, Steven A Boyd, Cassandra L Chatwin, Guo-Hua Chu, Anthony S Drager, Mitchell Edwards, Susan G Emeigh Hart, Cullen L Myers, Gopinath Rongala, Annie Stevenson, Kyoko Uehara, Fan Yi, Bibo Wang, Zhenwu Liu, Mingyue Wang, Zhichao Zhao, Xinming Zhou, Haiyan Zhao, Rok Tkavc, Ann E Jerse, Caleb M Stratton, Sandeepchowdary Bala, Christopher Davies, Daniel C Pevear, Christopher J Burns, Denis M Daigle, Stephen M Condon

    bioRxiv 2024.12.27.630553; doi: https://doi.org/10.1101/2024.12.27.630553. (under review)

  • Cefepime-Taniborbactam and Ceftibuten-Ledaborbactam Maintain Activity Against KPC Variants that Lead to Ceftazidime-Avibactam Resistance

    Cullen L Myers*, Annie Stevenson, Brittany Miller, Denis M Daigle, Tsuyoshi Uehara, Daniel C Pevear

    *: Corresponding authour

    Antimicrob Agents Chemother (2025) 0:e01511-24. doi: https://doi.org/10.1128/aac.01511-24

  • Microbiological characterization of VNRX-5236, a broad-spectrum β-lactamase inhibitor for rescue of the orally bioavailable cephalosporin ceftibuten as a carbapenem-sparing agent against strains of Enterobacterales expressing extended-spectrum β-lactamases and serine carbapenemases

    Cassandra L Chatwin, Jodie C Hamrick, Robert EL Trout, Cullen L Myers, Susan M Cusick, William J Weiss, Mark E Pulse, Luigi Xerri, Christopher J Burns, Gregory Moeck, Denis M Daigle, Kaitlyn John, Tsuyoshi Uehara, Daniel C Pevear

    Antimicrob Agents Chemother (2021) 65:10.1128/aac.00552-21. doi: https://doi.org/10.1128/aac.00552-21

  • VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosaw List Item

    Jodie C Hamrick, Jean-Denis Docquier, Tsuyoshi Uehara, Cullen L Myers, David A Six, Cassandra L Chatwin, Kaitlyn J John, Salvador F Vernacchio, Susan M Cusick, Robert EL Trout, Cecilia Pozzi, Filomena De Luca, Manuela Benvenuti, Stefano Mangani, Bin Liu, Randy W Jackson, Greg Moeck, Luigi Xerri, Christopher J Burns, Daniel C Pevear, Denis M Daigle

    Antimicrob Agents Chemother (2020) 64:10.1128/aac.01963-19. doi: https://doi.org/10.1128/aac.01963-19

  • A cell-based approach to characterize antimicrobial compounds through kinetic dose responsetem

    Craig R MacNair, Jonathan M Stokes, Shawn French, Cullen L Myers, Kali R Iyer, Eric D Brown

    Bioorg Med Chem (2016) 24 (24), 6315-6319. doi: https://doi.org/10.1016/j.bmc.2016.09.053

  • Identification of two phosphate starvation-induced wall teichoic acid hydrolases provides first insights into the degradative pathway of a key bacterial cell wall component

    Cullen L Myers, Franco KK Li, Byoung-Mo Koo, Omar M El-Halfawy, Shawn French, Carol A Gross, Natalie CJ Strynadka, Eric D Brown

    J Biol Chem (2016), Volume 291, Issue 50, 26066 - 26082. doi: https://doi.org/10.1074/jbc.M116.760447

  • Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase

    Cullen L Myers, Emily G Kuiper, Pei C Grant, Jennifer Hernandez, Graeme L Conn, John F Honek

    FEBS lett (2015) 589 (21), 3263-3270. doi: https://doi.org/10.1016/j.febslet.2015.09.028

  • Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

    Maya A Farha, Tomasz L Czarny, Cullen L Myers, Liam J Worrall, Shawn French, Deborah G Conrady, Yang Wang, Eric Oldfield, Natalie CJ Strynadka, Eric D Brown

    Proc. Natl. Acad. Sci. U.S.A.(2015) 112 (35) 11048-11053. doi: https://doi.org/10.1073/pnas.1511751112

  • Characterization of wall teichoic acid degradation by the bacteriophage ϕ29 appendage protein GP12 using synthetic substrate analogs

    Cullen L Myers, Ronald G Ireland, Teresa A Garrett, Eric D Brown

    J Biol Chem (2015), Volume 290, Issue 31, 19133 - 19145. doi: https://doi.org/10.1074/jbc.M115.662866

  • Molecular Interactions between Thiostrepton and the TipAS Protein from Streptomyces lividans

    Cullen L Myers, Jesse Harris, Jacky CK Yeung, John F Honek

    ChemBioChem, 15: 681-687 (2014) https://doi.org/10.1002/cbic.201300724

  • Semi-synthetic analogues of thiostrepton delimit the critical nature of tail region modifications in the control of protein biosynthesis and antibacterial activity

    Cullen L Myers, Pei C Hang, Grace Ng, Joshua Yuen, John F Honek

    Bioorg Med Chem 18 (12), 4231-4237 (2010) doi: https://doi.org/10.1016/j.bmc.2010.04.098